Science teacher Ryland Grace wakes up on a spaceship light years from home with no recollection of who he is or how he got there. As his memory returns, he begins to uncover his mission: solve the riddle of the mysterious substance causing the sun to die out. He must call on his scientific knowledge and unorthodox ideas to save everything on Earth from extinction.

Hunted by Miguel O'Hara's Spider Society and betrayed by his friends, Miles finds himself in the darkest corners of the Spider-Verse in search of a way home. Knowing that his family has been not only fractured but endangered by his calling, it's a race against the clock for Miles to travel across the wildest reaches of time and space to fight for and reunite everything he holds most dear.