In the early 1900s, a fiercely independent woman drives a rift between two brothers, igniting a saga that unfolds across two generations.

Fighting crime full-time as Spider-Man in a world that doesn't remember him—and the pressure of seeing his old friends move on without him—sparks a change in Peter Parker he may not have the power to control. But that transformation might also be the only thing that can stop a shocking new threat to the city and those he loves - a powerful villain no one can even see.